A Double-Blind Placebo-controlled Trial of Ursodeoxycholic Acid in the Prevention of Gallstones during Weight Loss after Vertical Banded Gastroplasty
| Autor: | C N Williams, R Gowan, Bernard Perey |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Randomization business.industry Endocrinology Diabetes and Metabolism General surgery Gallbladder Placebo-controlled study Gallstones Placebo medicine.disease Gastroenterology Ursodeoxycholic acid Regimen medicine.anatomical_structure Weight loss Internal medicine medicine Surgery medicine.symptom business medicine.drug |
| Zdroj: | Obesity Surgery. 3:257-259 |
| ISSN: | 1708-0428 0960-8923 |
| Popis: | One hundred and seven patients whose gallbladder was normal at the time of vertical banded gastroplasty (VBG) were considered for entry into a randomized placebo-controlled double-blind study to determine the effectiveness of ursodeoxycholic acid (UDCA) in preventing cholelithiasis during the period of weight loss. Twenty-one patients (20%) developed gallstones in the six-week period post-VBG and prior to randomization and were therefore excluded. Eighty-six patients were randomized at 6 weeks to active medication or placebo. Of these, 61 patients (71 %) completed the study. Twenty-five patients (29%) failed to complete the study because of incompliance, intolerance to the medication or pregnancy; 17 of these were in the active treatment group and eight were in the placebo group. None of the 27 patients treated with UDCA developed gallstones, whereas eight of 34 (24%) patients taking placebo developed gallstones. This difference was statistically significant (p = 0.0061). These results suggest that UDCA is fully effective in preventing gallstone formation following VBG in patients who follow the prescribed regimen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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