Orexins and feeding: special occasions or everyday occurrence?
| Autor: | Gareth Williams, Richard Morris, John C. Clapham, Xiao H Liu, Shelagh Wilson, Xue J. Cai, Jonathan R.S. Arch, Martyn L. Evans |
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| Rok vydání: | 2002 |
| Předmět: |
Blood Glucose
Leptin Food intake medicine.medical_specialty Hunger Physiology Clinical Biochemistry Hypoglycemia Inhibitory postsynaptic potential Satiety Response Biochemistry Eating Cellular and Molecular Neuroscience Endocrinology Internal medicine mental disorders medicine Animals Humans Neurons Orexins business.industry Neuropeptides digestive oral and skin physiology Intracellular Signaling Peptides and Proteins medicine.disease Orexin receptor Transgenic knockout Blockade Orexin nervous system Hypothalamus Hypothalamic Area Lateral Carrier Proteins business psychological phenomena and processes hormones hormone substitutes and hormone antagonists |
| Zdroj: | Regulatory Peptides. 104:1-9 |
| ISSN: | 0167-0115 |
| Popis: | Neurons expressing prepro-orexin, the precursor of orexin-A and -B, are found in the lateral hypothalamic area, a region classically implicated in driving feeding. Orexin-A induces feeding transiently when injected centrally, and food intake can be decreased when orexin action is disrupted by immunoneutralization of orexin-A, or by pharmacological blockade of orexin receptors, or by transgenic knockout of orexin. Here, we argue that orexin neurons may act to stimulate feeding in the short term, and that important regulatory signals may be a fall in plasma glucose (stimulatory), countered by satiety signals generated by eating, such as gastric distention (inhibitory). |
| Databáze: | OpenAIRE |
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