Histocompatibility Leukocyte Antigen-A2402-restricted Cytotoxic T Lymphocytes Recognizing Adenocarcinoma in Tumor-infiltrating Lymphocytes of Patients with Colon Cancer
| Autor: | Kyogo Itoh, Yutaka Ogata, Masanobu Nakao, Rumi Gohara, Hiroharu Isomoto, Kotaro Oizumi |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Cancer Research Cellular immunity Lung Neoplasms Esophageal Neoplasms chemical and pharmacologic phenomena Human leukocyte antigen Adenocarcinoma Biology Article Lymphocytes Tumor-Infiltrating Antigens Neoplasm HLA‐A2402 allele Tumor Cells Cultured medicine Humans Cytotoxic T cell Carcinoma Small Cell Killer Cells Lymphokine-Activated Aged Aged 80 and over Cytotoxic T lymphocyte HLA‐class I HLA-A Antigens Tumor-infiltrating lymphocytes hemic and immune systems Middle Aged medicine.disease Colon cancer Histocompatibility CTL Oncology Tumor‐infiltrating lymphocyte Colonic Neoplasms Immunology Carcinoma Squamous Cell Cancer research Interleukin-2 Female CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| DOI: | 10.1111/j.1349-7006.1997.tb00366.x |
| Popis: | To cast light on T cell-mediated specific immunity at the tumor site of colon cancer, we investigated whether interleukin-2 (IL-2)-activated tumor-infiltrating lymphocytes (TIL) from colon cancer show histocompatibility leukocyte antigen (HLA)-class I-restricted cytotoxicity against adenocarcinoma. IL 2-activated TIL from all four HLA-A24 patients examined lysed HLA-A2402 + adenocarcinomas, but not HLA-A2402 - tumors. Those of two of the four cases also lysed HLA-A2402 + squamous cell carcinomas. CD8 + cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2402+ adenocarcinomas were established from one CTL line. This CTL line produced IFN-γ upon recognition of an HLA-A2402 - adenocarcinoma transfected with HLA-A2402 cDNA. These results suggest the presence of HLA-A2402-restricted CTL recognizing adenocarcinoma at the tumor site of colon cancer. Furthermore, HLA-A31-restricted CTL activity was found in IL-2-activated TIL from one of two HLA-A31 + patients, suggesting the existence of HLA-class I-restricted CTL involving an allele other than A24. |
| Databáze: | OpenAIRE |
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