Suppression of uninvolved immunoglobulins defined by heavy/light chain pair suppression is a risk factor for progression of MGUS
| Autor: | Joanne T. Benson, L. J. Melton, Ola Landgren, Dirk R. Larson, S V Rajkumar, Robert A. Kyle, Shaji Kumar, James R. Cerhan, Raynell J. Clark, Jerry A. Katzmann, Terry M. Therneau, Angela Dispenzieri, Colin L. Colby, Arthur R. Bradwell |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Immunoglobulin gamma-Chains Immunoglobulin Variable Region Apoptosis Biology Malignancy Immunoglobulin light chain Monoclonal Gammopathy of Undetermined Significance Gastroenterology Article Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Internal medicine medicine Humans Risk factor Multiple myeloma Gene Rearrangement Hazard ratio Hematology medicine.disease Isotype Leukemia Myeloid Acute Oncology Immunology biology.protein Female Immunoglobulin Light Chains Somatic Hypermutation Immunoglobulin Antibody Immunoglobulin Heavy Chains Multiple Myeloma Biomarkers Monoclonal gammopathy of undetermined significance |
| Zdroj: | Leukemia. 27:208-212 |
| ISSN: | 1476-5551 0887-6924 |
| Popis: | We hypothesized that the suppression of uninvolved immunoglobulin in monoclonal gammopathy of undetermined significance (MGUS) as detected by suppression of the isotype-specific heavy and light chain (HLC-pair suppression) increases the risk of progression to malignancy. This approach required quantitation of individual heavy/light chains (for example, IgGλ in IgGκ MGUS patients). Of 1384 MGUS patients from Southeastern Minnesota seen at the Mayo Clinic from 1960 to 1994, baseline serum samples obtained within 30 days of diagnosis were available in 999 persons. We identified HLC-pair suppression in 27% of MGUS patient samples compared with 11% of patients with suppression of uninvolved IgG, IgA or IgM. HLC-pair suppression was a significant risk factor for progression (hazard ratio (HR), 2.3; 95% confidence interval (CI) 1.5–3.7; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|