Impact of frequent Bcl-2 expression on better prognosis in renal cell carcinoma patients
| Autor: | Toshiyuki Itoi, Kazutoshi Yamana, Kota Takahashi, F Tomita, Vladimir Bilim |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Proliferation index Biology renal cell carcinoma (RCC) Renal cell carcinoma medicine Carcinoma Humans Bcl-2 Carcinoma Renal Cell Survival analysis Aged Aged 80 and over TUNEL assay Molecular and Cellular Pathology apoptosis Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Kidney Neoplasms Genes bcl-2 Gene Expression Regulation Neoplastic Proto-Oncogene Proteins c-bcl-2 Oncology Apoptosis Cancer research Female Cell Division Kidney disease |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6601454 |
| Popis: | Previously, we reported that Bcl-2 was frequently expressed in renal cell carcinoma (RCC) specimens, but p53 mutation was a rare event. However, it was unclear whether Bcl-2 positivity was associated with the clinicopathological characteristics and prognosis in RCC. Therefore, we investigated the expression of Bcl-2 protein and its roles in 101 RCC specimens. In addition, the proliferation index (PI), apoptotic index (AI), caspase-3 and p53 expression were examined. The immunohistochemical method was applied for Bcl-2, caspase-3 and p53 protein expression. To investigate the proliferation activity and apoptosis of tumour cells, PI and AI were calculated based on Ki-67 and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labelling (TUNEL)-positive cells, respectively. Bcl-2 expression was detected in 72 out of 101 (71.3%) specimens. Bcl-2 positivity was inversely correlated with PI (P |
| Databáze: | OpenAIRE |
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