Pathogenicity of blood orf virus isolates in the development of dairy goat contagious pustular dermatitis
| Autor: | Xing-Ming Li, Ming-Jie Liu, Qin-Lei Fan, Xi-Dian Tang, Wei-Juan Li, Wen-Tao Ma, Dekun Chen, Hong-Yu Cheng |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
China viruses 030106 microbiology Virulence Disease Biology Polymerase Chain Reaction Microbiology Asymptomatic Disease Outbreaks law.invention Pathogenesis 03 medical and health sciences law Ecthyma Contagious medicine Animals Phylogeny Polymerase chain reaction Asymptomatic Diseases Goat Diseases General Veterinary Goats Outbreak Orf virus General Medicine Virology 030104 developmental biology medicine.symptom |
| Zdroj: | Veterinary Microbiology. 219:178-182 |
| ISSN: | 0378-1135 |
| DOI: | 10.1016/j.vetmic.2018.04.020 |
| Popis: | Contagious pustular dermatitis is an exanthematous zoonotic disease caused by the orf virus. Pandemic outbreaks of this disease cause great economic losses, while the pathogenesis of this disease still remains obscure. In this study, blood samples were collected from 628 asymptomatic goats across China for PCR-based virus detection. We detected the orf virus in the blood of asymptomatic goats. Moreover, the orf virus obtained from the blood of infected goats was infectious and induced typical symptoms of contagious pustular dermatitis after inoculation of uninfected dairy goats. In summary, our data provide evidence that asymptomatic animals may be carriers of orf virus. Our findings should contribute to elucidating the details underlying the pathogenesis of contagious pustular dermatitis. |
| Databáze: | OpenAIRE |
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