Circulating microRNAs panel as a diagnostic tool for discrimination of HCV-associated hepatocellular carcinoma
| Autor: | Azza A. Atef, Hamdy E. A. Ali, Abdel Hady A. Abdel Wahab, Heba Effat, Mohamed R. Ali, Emad K. Ahmed, Sabry K. Sharawi, Rehab Abdel Hameed, Zakaria Y. Abd Elmageed |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Carcinoma Hepatocellular Hepatitis C virus medicine.disease_cause Diagnosis Differential 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Internal medicine microRNA medicine Humans Circulating MicroRNA neoplasms Hepatology Receiver operating characteristic business.industry Liver Neoplasms Gastroenterology Diagnostic marker medicine.disease digestive system diseases 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma Immunology Biomarker (medicine) Female Differential diagnosis business |
| Zdroj: | Clinics and Research in Hepatology and Gastroenterology. 41:e51-e62 |
| ISSN: | 2210-7401 |
| DOI: | 10.1016/j.clinre.2017.06.004 |
| Popis: | Early diagnosis of hepatocellular carcinoma (HCC) can significantly improve the overall survival of HCC patients. However, current diagnostic markers are compromised and limited by their low sensitivity and specificity. In this work, circulating microRNAs (miRs) were utilized as a diagnostic tool to test their efficiency to segregate HCC and hepatitis C virus (HCV)-infected patients from healthy subjects. Nine HCC-related miRs (miR-21, miR-30c, miR-93, miR-122, miR-125b, miR-126, miR-130a, miR-193b and miR-222) were analyzed by Real-Time PCR in 86 serum samples; 34 HCC and 52 HCV patients in addition to 25 healthy subjects. The sensitivity and specificity of these miRs were assessed. Our results demonstrated that the median serum level of seven miRs was significantly reduced (P ranges from |
| Databáze: | OpenAIRE |
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