Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation

Autor: Christoph Handschin
Přispěvatelé: University of Zurich, Handschin, C
Rok vydání: 2009
Předmět:
medicine.medical_specialty
Physiology
Muscle Fibers
Skeletal
Peroxisome proliferator-activated receptor
Adipose tissue
610 Medicine & health
Inflammation
Motor Activity
Biology
Systemic inflammation
Models
Biological
10052 Institute of Physiology
2737 Physiology (medical)
Immune system
U6 Integrative Human Physiology
Physiology (medical)
Internal medicine
Coactivator
medicine
Animals
Humans
Obesity
Muscle
Skeletal
Heat-Shock Proteins
Pharmacology
chemistry.chemical_classification
Myositis
Skeletal muscle
1314 Physiology
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
3004 Pharmacology
Metabolism
Endocrinology
medicine.anatomical_structure
Adipose Tissue
chemistry
570 Life sciences
biology
Peroxisome proliferator-activated receptor alpha
medicine.symptom
Transcription Factors
Zdroj: Clinical and Experimental Pharmacology and Physiology. 36:1139-1143
ISSN: 1440-1681
0305-1870
DOI: 10.1111/j.1440-1681.2009.05275.x
Popis: 1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas in evolutionary terms a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other lifestyle-associated diseases has increased in relevance in Western societies in the past 100 years. 2. Traditionally, fat tissue has been considered as the major source of pro-inflammatory secreted factors in these pathologies. However, in recent years the contribution of other tissues to disease-causing chronic inflammation has been increasingly appreciated. 3. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) is one of the key regulatory factors in active skeletal muscle. Aberrant expression of PGC-1alpha in inactive muscle fibres could be linked to a sedentary lifestyle, persistent systemic inflammation and a higher risk for many chronic diseases. Accordingly, modulation of PGC-1alpha activity in skeletal muscle may have a broad range of therapeutic effects. Here, recent advances in the understanding of the role of muscle PGC-1alpha in health and disease are reviewed.
Databáze: OpenAIRE
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