Iodine-imine Synergistic Promoted Povarov-Type Multicomponent Reaction for the Synthesis of 2,2′-Biquinolines and Their Application to a Copper/Ligand Catalytic System

Autor:	Yan-Ting Gao, Yan-Ping Zhu, Qi-Qi Hu, Jing-Jing Gao, Hong-Xiao Mu, Jia-Chen Sun, Kai-Rui Yang, Ya-Nan Zheng, Yi-Ming Li
Rok vydání:	2021
Předmět:	Annulation Organic Chemistry Imine Kornblum oxidation Aromatization Halogenation Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound chemistry Povarov reaction Physical and Theoretical Chemistry Methyl group
Zdroj:	Organic Letters. 23:9000-9005
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c03546
Popis:	An efficient iodine-imine synergistic promoted Povarov-type multicomponent reaction was reported for the synthesis of a practical 2,2'-biquinoline scaffold. The tandem annulation has reconciled iodination, Kornblum oxidation, and Povarov aromatization, where the methyl group of the methyl azaarenes represents uniquely reactive input in the Povarov reaction. This method has broad substrate scope and mild conditions. Furthermore, these 2,2'-biquinoline derivatives had been directly used as bidentate ligands in metal-catalyzed reactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7115f69356ba1c4a53c3cad04177b86 https://doi.org/10.1021/acs.orglett.1c03546 Zobrazit plný text záznamu