Expression of pp60c-src in human small cell and non-small cell lung carcinomas
| Autor: | E.A. Kogan, I.B. Zborovskaya, N.N. Mazurenko, F. L. Kisseljov |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Lung Neoplasms medicine.drug_class Cell Immunoblotting Proto-Oncogene Proteins pp60(c-src) Adenocarcinoma Monoclonal antibody Immunoenzyme Techniques Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans Carcinoma Small Cell Rous sarcoma virus Lung biology Respiratory disease biology.organism_classification medicine.disease medicine.anatomical_structure Oncology Carcinoma Squamous Cell Immunohistochemistry Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | European journal of cancer (Oxford, England : 1990). 28(2-3) |
| ISSN: | 0959-8049 |
| Popis: | c- src protein was found in 60% of lung carcinomas (20 of 33 cases or primary tumours) by immunoblotting with a monoclonal antibody (Mab 327) and immunohistochemistry with serum from rabbits bearing tumours induced by Rous sarcoma virus. src protein expression was assessed in 4 small cell lung carcinomas and in an atypical carcinoid of neuroendocrine origin. However, pp60 c-src was also found in non-small cell lung carcinomas: in 60–80% of adenocarcinomas and bronchiolo-alveolar cancers and in 50% of squamous cell carcinomas. In the squamous cell carcinomas, src protein was expressed more frequently in poorly differentiated than in well and moderately differentiated carcinomas. Expression of pp60 c-src was not found in epithelial cells of histologically unchanged lung tissues. These results show that pp60 c-src may be activated in human lung carcinomas of different histopathological types. |
| Databáze: | OpenAIRE |
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