Non-invasive prenatal diagnosis of β-thalassemia by detection of the cell-free fetal DNA in maternal circulation: a systematic review and meta-analysis
| Autor: | Hossein Jalalli, Ali Banihashemi, Mohammad Reza Shiran, Pooria Gill, Mandana Zafari, Fatemeh Fatahi, Abbass Alipour, Mehrnoush Kosaryan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Thalassemia Prenatal diagnosis Biology Bioinformatics Sensitivity and Specificity 03 medical and health sciences Fetus 0302 clinical medicine Pregnancy Prenatal Diagnosis medicine Humans Genetics 030219 obstetrics & reproductive medicine Cell-Free System beta-Thalassemia Reproducibility of Results Beta thalassemia DNA Hematology General Medicine medicine.disease 030104 developmental biology Cell-free fetal DNA Meta-analysis Mutation (genetic algorithm) Female |
| Zdroj: | Annals of Hematology. 95:1341-1350 |
| ISSN: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-016-2620-3 |
| Popis: | The discovery of fetal DNA (f-DNA) opens the possibility of early non-invasive procedure for detection of paternally inherited mutation of beta-thalassemia. Since 2002, some studies have examined the sensitivity and specificity of this method for detection of paternally inherited mutation of thalassemia in pregnant women at risk of having affected babies. We conducted a systematic review of published articles that evaluated using this method for early detection of paternally inherited mutation in maternal plasma. A sensitive search of multiple databases was done in which nine studies met our inclusion criteria. The sensitivity and specificity was 99 and 99 %, respectively. The current study found that detection of paternally inherited mutation of thalassemia using analysis of cell-free fetal DNA is highly accurate. This method could replace conventional and invasive methods. |
| Databáze: | OpenAIRE |
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