A diurnal rhythm in the excretion of neutral reducing lipids by man and its relation to the 17-ketosteroid rhythm
| Autor: | Louise P. Romanoff, Gregory Pincus, James J. Carlo |
|---|---|
| Rok vydání: | 1948 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Urine Biology Biochemistry Excretion chemistry.chemical_compound Endocrinology Rhythm Internal medicine Ketosteroid medicine Humans Circadian rhythm Morning Biochemistry (medical) Biological Transport Lipids 17-Ketosteroids Body Fluids Circadian Rhythm chemistry Corticosteroid |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 8(3) |
| ISSN: | 0021-972X |
| Popis: | THE observation that there is a diurnal rhythm in urinary ketosteroid excretion (1, 2, 3) and that this may be related to stress-stimulated adrenocortical secretion (2) led us to examine other possible indices of adrenocortical secretion. The development of a method for measuring neutral reducing lipid in urine by Heard and Sobel (4) and the indications that this material represents in large part corticosteroid possessing reducing activity by virtue of its α-ketol sidechain (4, 5, 6), offered an opportunity to assess the diurnal changes in excretion of adrenocortical substances, which are entirely different from those of the 17-ketosteroids. MATERIAL AND METHODS Twenty-four normal healthy men ranging in age from 24 to 72 years (see Table 1) were the subjects of this investigation. Urine was collected over a 24-hour period in three lots covering approximately the periods 11 p.m. to 7 a.m. (sleep), 7 a.m. to 11 a.m. (morning) and 11 a.m. to 11 p.m. (day). |
| Databáze: | OpenAIRE |
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