Ascorbic acid levels in various tissues, plasma and urine of mice during aging
| Autor: | Kentaro Shimokado, Akiko Amano, Naoki Maruyama, Akihito Ishigami, Mizuki Iwama |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Aging Urinary system Medicine (miscellaneous) Spleen Urine Ascorbic Acid Mice Internal medicine Adrenal Glands Testis medicine Animals Muscle Skeletal Lung Skin Brain Chemistry Kidney Nutrition and Dietetics Vitamin C Cerebrum Chemistry Myocardium Ascorbic acid Small intestine Mice Inbred C57BL medicine.anatomical_structure Endocrinology Biochemistry Liver |
| Zdroj: | Journal of nutritional science and vitaminology. 58(3) |
| ISSN: | 1881-7742 |
| Popis: | Here we quantified ascorbic acid (AA) levels in 14 tissues, plasma and urine of C57BL/6 male mice to track its turnover during 3 to 30 mo of aging. The AA content of adrenal glands and testes decreased somewhat with age, and eventually rose, but increased in the spleen, lungs, eyes and heart. AA levels rose in the liver, skin and skeletal muscles from 6 to 12 mo of age, but declined from 12 to 24 mo. In the cerebellum, cerebrum, small intestine, kidney and plasma, amounts of AA remained almost constant as the animals aged. Most notably, urinary AA decreased markedly until becoming almost undetectable at 24 and 30 mo of age. Collectively, these results, which compare changes in AA levels in specific physiologic targets throughout the aging process, strongly suggest that the AA synthesizing capacity declines over time to become a major factor in senescence-related diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|