The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation
| Autor: | Timothy D. Garver, Vann Bennett, Shmuel Tuvia |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Ankyrins
Cytoplasm L1 family Molecular Sequence Data Cell Separation Ankyrin binding Biology chemistry.chemical_compound Tumor Cells Cultured Ankyrin Amino Acid Sequence Nerve Growth Factors Phosphorylation Cell Aggregation chemistry.chemical_classification Multidisciplinary Cell adhesion molecule Tyrosine phosphorylation Biological Sciences Cell sorting Cell aggregation Cell biology chemistry Tyrosine Cell Adhesion Molecules Protein Binding |
| Zdroj: | Proceedings of the National Academy of Sciences. 94:12957-12962 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.94.24.12957 |
| Popis: | Cell–cell recognition and patterning of cell contacts have a critical role in mediating reversible assembly of a variety of transcellular complexes in the nervous system. This study provides evidence for regulation of cell interactions through modulation of ankyrin binding to neurofascin, a member of the L1CAM family of nervous system cell adhesion molecules. The phosphorylation state of the conserved FIGQY tyrosine in the cytoplasmic domain of neurofascin regulates ankyrin binding and governs neurofascin-dependent cell aggregation as well as cell sorting when neurofascin is expressed in neuroblastoma cells. These findings suggest a general mechanism for the patterning of cell contact based on external signals that regulate tyrosine phosphorylation of L1CAM members and modulate their binding to ankyrin. |
| Databáze: | OpenAIRE |
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