Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease
| Autor: | Alberto Villarejo-Galende, Elena García-Arcelay, Gerard Piñol-Ripoll, Antonio del Olmo-Rodríguez, Félix Viñuela, Mercè Boada, Emilio Franco-Macías, Almudena Ibañez de la Peña, Mario Riverol, Albert Puig-Pijoan, Pedro Abizanda-Soler, Rafael Arroyo, Miquel Baquero-Toledo, Inmaculada Feria-Vilar, Mircea Balasa, Ángel Berbel, Eloy Rodríguez-Rodríguez, Alba Vieira-Campos, Guillermo García-Ribas, Silvia Rodrigo-Herrero, Ángeles Terrancle, Daniel Prefasi, Alberto Lleó, Jorge Maurino |
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| Přispěvatelé: | Universidad de Cantabria, Roche |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Quality of life
Amyloid Early-stage tau proteins cerebrospinal fluid White matter lesions Magnetic resonance imaging Alzheimer Disease Surveys and Questionnaires White matter hyperintensities magnetic resonance imaging Tau proteins Humans Cognitive Dysfunction Aged Depression General Neuroscience white matter lesions amyloid biomarkers General Medicine white matter hyperintensities Psychiatry and Mental health Clinical Psychology Stigma Cerebrospinal fluid Quality of Life Hopelessness Self Report Geriatrics and Gerontology Alzheimer’s disease Biomarkers |
| Zdroj: | J Alzheimers Dis . 2022;90(2):719-726 Journal of Alzheimer's disease : JAD r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 1387-2877 |
| Popis: | [Background] There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. [Objective] The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. [Methods] A multicenter, non-interventional study was conducted including patients of 50–90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score ≥22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5.–1.0. The Quality of Life in Alzheimer ’s Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman’s rank correlations. [Results] A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. [Conclusion] Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment. This study was funded by the Medical Department of Roche Farma Spain (ML42346). |
| Databáze: | OpenAIRE |
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