Synthesis of 2,3-Disubstituted 4-Ethoxycarbonyl-β-carbolin-1-ones: Application to the Synthesis of SL651498 and Its Analogue

Autor:	Iwao Hachiya, Ryoya Miura, Takahide Hashimoto, Shinsuke Goto
Rok vydání:	2020
Předmět:	Addition reaction medicine.drug_class Chemistry General Chemical Engineering General Chemistry Anxiolytic Medicinal chemistry Article Intramolecular force medicine QD1-999 Amination Conjugate
Zdroj:	ACS Omega ACS Omega, Vol 5, Iss 25, Pp 15631-15656 (2020)
ISSN:	2470-1343
Popis:	Synthesis of 2,3-disubstituted 4-ethoxycarbonyl-β-carbolin-1-ones is developed using palladium-catalyzed intramolecular amination of 3-amino-4-(2-bromophenyl)-2-pyridones prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl imines. The method was applied to the total syntheses of SL651498 exhibiting anxiolytic activity and its analogue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7088d304caec21f392dba96e9ee9299 https://pubmed.ncbi.nlm.nih.gov/32637839 Zobrazit plný text záznamu