Inulin-Type Fructan Supplementation of 3- to 6-Year-Old Children Is Associated with Higher Fecal Bifidobacterium Concentrations and Fewer Febrile Episodes Requiring Medical Attention

Autor: Manuela Sailer, Carolin Sieland, Sotirios Vasileiadis, Szimonetta Lohner, Günther Boehm, Károly Berényi, Krisztina Mihalyi, Sara Soldi, Tamás Decsi, Viktoria Jakobik, Stephan Theis
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Nutrition and Disease
medicine.medical_treatment
Medicine (miscellaneous)
respiratory tract infections
Severity of Illness Index
law.invention
Feces
0302 clinical medicine
prevention
Randomized controlled trial
microbiota composition
law
double-blind method
Child
Nutrition and Dietetics
Respiratory tract infections
Incidence
Incidence (epidemiology)
Inulin
Diarrhea
Child
Preschool
Female
medicine.symptom
medicine.medical_specialty
Fever
Colon
gastrointestinal infections
030209 endocrinology & metabolism
Infections
Placebo
03 medical and health sciences
children
Internal medicine
Severity of illness
medicine
Humans
Sinusitis
030109 nutrition & dietetics
business.industry
Prebiotic
Fructans
Gastrointestinal Microbiome
stool consistency
Lactobacillus
Prebiotics
randomized controlled trial
placebo
Bifidobacterium
business
Breast feeding
Zdroj: The Journal of Nutrition
ISSN: 0022-3166
DOI: 10.1093/jn/nxy120
Popis: Background Inulin-type fructans used in formula have been shown to promote microbiota composition and stool consistency closer to those of breastfed infants and to have beneficial effects on fever occurrence, diarrhea, and incidence of infections requiring antibiotic treatment in infants. Objectives The primary study aim was to explore whether prophylactic supplementation with prebiotic fructans is able to influence the frequency of infectious diseases in kindergarten children during a winter period. A secondary objective was to ascertain the effect on the intestinal microbiota. Methods 142 boys and 128 girls aged 3–6 y were randomly allocated to consume 6 g/d fructans or maltodextrin for 24 wk. At baseline, stool samples were collected for microbiota analysis and anthropometric measurements were made. During the intervention period diagnoses were recorded by physicians, whereas disease symptoms, kindergarten absenteeism, dietary habits, and stool consistency were recorded by parents. Baseline measurements were repeated at wk 24. Results In total 219 children finished the study. Both the relative abundance of Bifidobacterium (P
Databáze: OpenAIRE
Externí odkaz: