Cocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus Accumbens
| Autor: | Hyojin Lee, Eun Sol Jung, Hye Ri Sim, Ja Hyun Baik |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Raclopride
nucleus accumbens business.industry Addiction media_common.quotation_subject Antagonist cocaine behavioral sensitization Nucleus accumbens Pharmacology Cellular and Molecular Neuroscience medicine.anatomical_structure Dopamine receptor Dopamine receptor D2 dopamine receptor medicine Original Article addiction Neurology (clinical) business Microinjection Sensitization media_common medicine.drug |
| Zdroj: | Experimental Neurobiology |
| ISSN: | 2093-8144 1226-2560 |
| Popis: | To determine the role of dopamine D2 receptor (D2R) in the nucleus accumbens (NAc) core in cocaine-induced behavioral sensitization, D2R antagonist, raclopride was bilaterally microinjected (2.5 or 5 nmol) into the NAc core of WT and D2R(-/-) mice and the initiation and expression phase of cocaine-mediated locomotor sensitization were analyzed. WT and D2R knockout (D2R(-/-)) mice received bilateral injections of either saline, or raclopride at the NAc core 30 min before each of five daily repeated injections of saline or cocaine (15 mg/kg i.p.). Following 2 weeks of withdrawal after repeated exposure to cocaine, the animals were pre-treated with an intra-accumbal injection of vehicle or raclopride before receiving a systemic cocaine challenge for the expression of sensitization. Animals which had been microinjected raclopride into NAc core displayed the enhancement of cocaine-induced behavioral response for the initiation but also for the expression of sensitization in WT as well as in D2R(-/-) mice, which was thus unaltered as compared to vehicle-injected control group. These results suggest that D2R in NAc core is not involved in cocaine-induced behavioral sensitization. |
| Databáze: | OpenAIRE |
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