In vitro antibiotic susceptibility of Francisella tularensis isolated from humans and animals
| Autor: | R Schildt, Markku Koskela, J Karhukorpi, Irma Ikäheimo, H Syrjälä |
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| Rok vydání: | 2000 |
| Předmět: |
DNA
Bacterial Microbiology (medical) Tetracycline Animals Wild Microbial Sensitivity Tests Microbiology medicine Animals Humans Pharmacology (medical) Francisella tularensis Tularemia Antibacterial agent Pharmacology biology Arvicolinae Reverse Transcriptase Polymerase Chain Reaction biochemical phenomena metabolism and nutrition biology.organism_classification Virology Grepafloxacin Anti-Bacterial Agents Ciprofloxacin Trovafloxacin Infectious Diseases Streptomycin Electrophoresis Polyacrylamide Gel Gentamicin Rabbits medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 46:287-290 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/46.2.287 |
| Popis: | The in vitro susceptibility of 38 strains of Francisella tularensis (biovar F. tularensis palaearctica) was determined using Etests on cysteine heart agar plates with 2% haemoglobin. All strains were susceptible to the antibiotics traditionally used to treat tularaemia, such as streptomycin (MIC(90) 4.0 mg/L), tetracycline (MIC(90) 0.38 mg/L) and chloramphenicol (MIC(90) 0.38 mg/L), and to aminoglycosides, such as tobramycin (MIC(90) 1.5 mg/L) and gentamicin (MIC(90) 1.0 mg/L). The quinolones examined had low MIC(90)s: ciprofloxacin, 0.016 mg/L; levofloxacin, 0.016 mg/L; grepafloxacin, 0.047 mg/L; and trovafloxacin, 0.032 mg/L. In contrast, all the strains were resistant to beta-lactams and azithromycin. Quinolones thus seem to be promising drugs for the treatment of tularaemia. |
| Databáze: | OpenAIRE |
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