Correlation of serum ribavirin concentration with pretreatment renal function estimates in patients with chronic hepatitis C receiving combination antiviral therapy with peginterferon and ribavirin
| Autor: | Makoto Tanikawa, Yasuhiro Hisanaga, Kazuhiko Hayashi, H. Atsumi, Hidemi Goto, Akira Kanamori, Yoshiaki Katano, S. Nakano, Takashi Honda, Takashi Kumada, H. Toyoda, T. Arakawa, Seiki Kiriyama, Y Sone |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Serum medicine.medical_specialty Metabolic Clearance Rate viruses Statistics as Topic Renal function Interferon alpha-2 Kidney Function Tests Antiviral Agents Gastroenterology Polyethylene Glycols chemistry.chemical_compound Asian People Chronic hepatitis Virology Internal medicine Ribavirin medicine Humans In patient Cystatin C Adverse effect Aged Creatinine Hepatology biology business.industry Antiviral therapy Interferon-alpha virus diseases Hepatitis C Chronic Middle Aged biochemical phenomena metabolism and nutrition Cystatins Recombinant Proteins digestive system diseases Infectious Diseases chemistry Immunology biology.protein Female business |
| Zdroj: | Journal of Viral Hepatitis. 15:651-658 |
| ISSN: | 1365-2893 1352-0504 |
| Popis: | Summary. Serum ribavirin concentration is an important factor in antiviral therapy in combination with peginterferon (PEG-IFN) and ribavirin for patients with chronic hepatitis C in terms of both beneficial and adverse effects. We evaluated whether the serum ribavirin concentration can be predicted on the basis of renal function estimates. Serum creatinine and cystatin C concentrations were measured at the start of treatment in a total of 148 patients with chronic hepatitis C who underwent combination PEG-IFN and ribavirin therapy. Creatinine clearance (CrCl) and total clearance of ribavirin (CL/F) were calculated on the basis of the serum creatinine level. The glomerular filtration rate was calculated with two different formulae on the basis of the serum cystatin C level. These values were compared with serum ribavirin concentrations 4 weeks after the start of therapy. The cystatin C level increased with the progression of liver fibrosis, whereas the creatinine level was constant regardless of the degree of liver fibrosis. Significant correlation was not observed between the serum ribavirin concentration and serum creatinine level, cystatin C level, or calculated renal function estimates. However, significant correlation was found between the serum ribavirin concentration and CrCl and CL/F in patients who were given ribavirin >800 mg/day. Overall, renal function estimates do not correlate with the serum ribavirin concentration in Japanese patients with chronic hepatitis C who undergo combination PEG-IFN and ribavirin therapy. Serum creatinine-based renal function estimates might be predictive for the serum ribavirin concentration only in patients with a daily ribavirin intake of 800 mg or more. |
| Databáze: | OpenAIRE |
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