Impact of Moderate Altitude on Pro-Inflammatory Cytokines in Healthy Volunteers
| Autor: | Marcus Franz, Michael Lichtenauer, Catharina Schreiber, Uta C. Hoppe, Christiana Schernthaner, Ilonka Rohm, Bjoern Goebel, H. R. Figulla, Rudin Pistulli, Christoph Edlinger, Vera Paar, Christian Jung |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Angiogenesis medicine.medical_treatment 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Internal medicine Healthy volunteers medicine Humans Interleukin 8 Interleukin 6 Hypoxia biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Altitude Interleukin-8 Hypoxia (medical) Healthy Volunteers Endocrinology Cytokine biology.protein Cytokines Tumor necrosis factor alpha medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Clinical laboratory. 63(9) |
| ISSN: | 1433-6510 |
| Popis: | BACKGROUND The induction of microvascular inflammation and the effects on cytokine production in blood due to hypoxia has been shown in the past. We have previously reported a statistically significant increase of the pro-inflammatory cytokine interleukin-8 (IL-8) in normobaric hypoxia in the setting of a hypoxia-chamber. In the present study, we sought to analyze plasma levels of inflammatory cytokines in a real-life stetting in order to foster our knowledge on hypoxia induced microvascular inflammation at moderate altitude. METHODS Pro-inflammatory cytokines (IL-8, IL-6, TNF-α) were measured in an experimental field study, exposing 18 healthy volunteers to moderate hypoxia while staying at a mountain lodge in Diavolezza, Switzerland (2978 meters above sea level). Plasma cytokine levels were measured by ELISA. RESULTS In contradiction to our results in a normobaric hypoxia-chamber, exposure to moderate hypoxia led to a significant decrease of plasma IL-8 levels in a real-life setting (from 2.902 (1.046 - 4.984) pg/mL to 1.395 (0.698 - 3.712) pg/mL, p = 0.034). Concentrations of IL-6 and TNF-α did not show statistically significant changes in comparison to baseline measurements. CONCLUSIONS The results of this study show a decrease of proinflammatory cytokine IL-8 in a real life setting of moderate altitude in healthy individuals. Initiation of angiogenesis or subliminal stimulus for an altitude-induced inflammatory reaction may be explanations for this unexpected finding. |
| Databáze: | OpenAIRE |
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