Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
| Autor: | John F. Elliott, Joy Davis, Christian Toso, Shaheed Merani, A. M. James Shapiro, Juliet Emamaullee, Aducio Thiesen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Diabetes Mellitus Type 1/*immunology Population Islets of Langerhans Transplantation Enzyme-Linked Immunosorbent Assay Biology medicine.disease_cause Autoimmunity 03 medical and health sciences Mice 0302 clinical medicine Mice Inbred NOD Diabetes mellitus T-Lymphocytes Helper-Inducer/*immunology/*transplantation Internal Medicine medicine Animals education Autoantibodies/analysis Recombinant Proteins/immunology 030304 developmental biology NOD mice Autoantibodies Homeodomain Proteins Mice Knockout 0303 health sciences Type 1 diabetes education.field_of_study Systemic lupus erythematosus ddc:617 Glutamate Decarboxylase Autoantibody Interleukin Antibodies Monoclonal T-Lymphocytes Helper-Inducer medicine.disease Flow Cytometry Adoptive Transfer Recombinant Proteins 3. Good health Diabetes Mellitus Type 1 Immunology Disease Progression Original Article Homeodomain Proteins/genetics Immunology and Transplantation Glutamate Decarboxylase/genetics/immunology 030215 immunology |
| Zdroj: | Diabetes Diabetes, Vol. 58, No 6 (2009) pp. 1302-1311 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | OBJECTIVE The T helper 17 (Th17) population, a subset of CD4-positive T-cells that secrete interleukin (IL)-17, has been implicated in autoimmune diseases, including multiple sclerosis and lupus. Therapeutic agents that target the Th17 effector molecule IL-17 or directly inhibit the Th17 population (IL-25) have shown promise in animal models of autoimmunity. The role of Th17 cells in type 1 diabetes has been less clear. The effect of neutralizing anti–IL-17 and recombinant IL-25 on the development of diabetes in NOD mice, a model of spontaneous autoimmune diabetes, was investigated in this study. RESEARCH DESIGN AND METHODS AND RESULTS Although treatment with either anti–IL-17 or IL-25 had no effect on diabetes development in young ( CONCLUSIONS These studies suggest that Th17 cells are involved in the pathogenesis of autoimmune diabetes. Further development of Th17-targeted therapeutic agents may be of benefit in this disease. |
| Databáze: | OpenAIRE |
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