Characterization of Staphylococcus aureus from Distinct Geographic Locations in China: An Increasing Prevalence of spa-t030 and SCCmec Type III

Autor: Yanwen Gong, Jiyong Yang, Xiangzhao Meng, Li Han, Yulong Zhang, Mengqiang Zhang, Zhengxiang Liu, Jie Xiong, Zhongyi Lu, Changjian Zhang, Jingya Zhao, Zhanke Wang, Fang Wang, Yong Chen, Xuqin Wu, Li-Bo Duo
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Bacterial Diseases
Genotyping Techniques
Epidemiology
Staphylococcus
lcsh:Medicine
Drug resistance
medicine.disease_cause
Pathology and Laboratory Medicine
Medicine and Health Sciences
Clinical Epidemiology
Public and Occupational Health
lcsh:Science
Molecular Epidemiology
Cross Infection
Multidisciplinary
Virulence
Medical microbiology
Staphylococcal Infections
Ciprofloxacin
Infectious Diseases
Staphylococcus aureus
Research Design
Genetic Epidemiology
Gentamicin
medicine.drug
Research Article
Methicillin-Resistant Staphylococcus aureus
China
Clinical Pathology
Clinical Research Design
Biology
Staphylococcal infections
Research and Analysis Methods
Microbiology
Infectious Disease Epidemiology
Antibiotic resistance
Bacterial Proteins
Diagnostic Medicine
Drug Resistance
Bacterial
medicine
Humans
Biology and life sciences
Population Biology
SCCmec
lcsh:R
biochemical phenomena
metabolism
and nutrition
medicine.disease
bacterial infections and mycoses
Methicillin-resistant Staphylococcus aureus
Microbial pathogens
Clinical Microbiology
lcsh:Q
Bacterial pathogens
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e96255 (2014)
ISSN: 1932-6203
Popis: Staphylococcus aureus belongs to one of the most common bacteria causing healthcare and community associated infections in China, but their molecular characterization has not been well studied. From May 2011 to June 2012, a total of 322 non-duplicate S. aureus isolates were consecutively collected from seven tertiary care hospitals in seven cities with distinct geographical locations in China, including 171 methicillin sensitive S. aureus (MSSA) and 151 MRSA isolates. All isolates were characterized by spa typing. The presence of virulence genes was tested by PCR. MRSA were further characterized by SCCmec typing. Seventy four and 16 spa types were identified among 168 MSSA and 150 MRSA, respectively. One spa type t030 accounted for 80.1% of all MRSA isolates, which was higher than previously reported, while spa-t037 accounted for only 4.0% of all MRSA isolates. The first six spa types (t309, t189, t034, t377, t078 and t091) accounted for about one third of all MSSA isolates. 121 of 151 MRSA isolates (80.1%) were identified as SCCmec type III. pvl gene was found in 32 MSSA (18.7%) and 5 MRSA (3.3%) isolates, with ST22-MSSA-t309 as the most commonly identified strain. Compared with non-epidemic MRSA clones, epidemic MRSA clones (corresponding to ST239) exhibited a lower susceptibility to rifampin, ciprofloxacin, gentamicin and trimethoprim-sulfamethoxazole, a higher prevalence of sea gene and a lower prevalence of seb, sec, seg, sei and tst genes. The increasing prevalence of multidrug resistant spa-t030 MRSA represents a major public health problem in China.
Databáze: OpenAIRE
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