BRCA1 and BRCA2 mRNA-expression prove to be of clinical impact in ovarian cancer

Autor: Sigurd Lax, Christian Marth, S Wenzel, C Degasper, I Tsibulak, Alain G. Zeimet, H Fiegl, Susanne Sprung, Verena Wieser, Giridhar Shivalingaiah
Rok vydání: 2018
Předmět:
Adult
0301 basic medicine
Cancer Research
medicine.medical_specialty
endocrine system diseases
medicine.medical_treatment
Mrna expression
Context (language use)
Carcinoma
Ovarian Epithelial
Gastroenterology
Article
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Ovarian cancer
Internal medicine
medicine
Carcinoma
Humans
skin and connective tissue diseases
Aged
Platinum
Aged
80 and over
BRCA2 Protein
Ovarian Neoplasms
Chemotherapy
Molecular medicine
BRCA1 Protein
business.industry
Gene Expression Profiling
Case-control study
Cytoreduction Surgical Procedures
Translational research
Middle Aged
Prognosis
medicine.disease
DNA Damage Repair
Up-Regulation
Gene Expression Regulation
Neoplastic
Serous fluid
Treatment Outcome
030104 developmental biology
Oncology
Case-Control Studies
030220 oncology & carcinogenesis
Mutation
Female
business
Zdroj: British Journal of Cancer
ISSN: 1532-1827
0007-0920
Popis: Background Mutations in BRCA1 and BRCA2 are associated with better survival in ovarian cancer (OC) patients due to a better response to platinum-based chemotherapy. However, the impact of the BRCA1/2 mRNA-expression is not well characterized in OC. Patients and methods We investigated BRCA1/2 mRNA-expression in 12 non-neoplastic fallopian tubes and 201 epithelial OCs in relation to their clinical characteristics. Results We found higher BRCA1/2 mRNA-expression in OCs compared to controls (P = 0.011, P
Databáze: OpenAIRE
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