Molecular landscape of thymic epithelial tumors

Autor:	Cristian Ortiz-Villalón, Julia Prays
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty Thymoma Thymus Neoplasms Gene mutation Biology Anterior mediastinum medicine.disease Pathology and Forensic Medicine Chromosomal Abnormality Mutation medicine Humans Neoplasms Glandular and Epithelial Thymic carcinoma
Zdroj:	Seminars in diagnostic pathology. 39(2)
ISSN:	0740-2570
Popis:	Thymic epithelial tumors (TETs) are extremely rare and represent the most frequent tumors of the anterior mediastinum originating from epithelial cells in the thymus. Thymic epithelial tumors include thymomas (TM), thymic carcinomas (TC) and thymic neuroendocrine neoplasms (TNEN). Thymomas are the most predominant and are associated with autoimmune diseases. The available data suggests that the different histological subtypes have specific molecular alterations. Thymic carcinoma shows recurrent gene mutations, but further investigations are needed to understand the role of those mutations in the pathogenetic of the TETs. Some of the new emerging identified molecular alterations have the potential to offer new targeted therapies opening new possibilities for the treatment of thymic epithelial tumors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6febcc91084cf4a80abbb0d8df44058 https://pubmed.ncbi.nlm.nih.gov/34272124 Zobrazit plný text záznamu