Impact of neonatal asphyxia and hind limb immobilization on musculoskeletal tissues and S1 map organization: implications for cerebral palsy
| Autor: | Jacques-Olivier Coq, Fabrizio Strata, Fayez F. Safadi, Mary F. Barbe, Nancy N. Byl, Michael M. Merzenich, Michaël Russier |
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| Přispěvatelé: | Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS - Inserm U1072), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2007 |
| Předmět: |
Cartilage
Articular Male MESH: Asphyxia Movement disorders MESH: Random Allocation [SDV]Life Sciences [q-bio] MESH: Musculoskeletal Abnormalities MESH: Rats Sprague-Dawley Hindlimb MESH: Animals Newborn MESH: Myofibrils Rats Sprague-Dawley Random Allocation Myofibrils MESH: Animals MESH: Brain Mapping MESH: Muscle Skeletal Brain Mapping MESH: Hindlimb Anatomy Muscle atrophy medicine.anatomical_structure Neurology Hindlimb Suspension MESH: Hindlimb Suspension Intercellular Signaling Peptides and Proteins Female medicine.symptom Psychology MESH: Connective Tissue Growth Factor Motor cortex MESH: Cerebral Palsy MESH: Rats Brain damage MESH: Somatosensory Cortex Cerebral palsy Immediate-Early Proteins Asphyxia Developmental Neuroscience MESH: Analysis of Variance medicine Animals MESH: Intercellular Signaling Peptides and Proteins Muscle Skeletal Analysis of Variance Cerebral Palsy Connective Tissue Growth Factor MESH: Immediate-Early Proteins Somatosensory Cortex medicine.disease MESH: Male Perinatal asphyxia Musculoskeletal Abnormalities Rats Disease Models Animal Animals Newborn MESH: Cartilage Articular MESH: Disease Models Animal MESH: Female Neuroscience |
| Zdroj: | Experimental Neurology Experimental Neurology, 2008, 210 (1), pp.95-108. ⟨10.1016/j.expneurol.2007.10.006⟩ |
| ISSN: | 0014-4886 1090-2430 |
| DOI: | 10.1016/j.expneurol.2007.10.006⟩ |
| Popis: | Cerebral palsy (CP) is a complex disorder of locomotion, posture and movements resulting from pre-, peri- or postnatal damage to the developing brain. In a previous study (Strata, F., Coq, J.O., Byl, N.N., Merzenich, M.M., 2004. Comparison between sensorimotor restriction and anoxia on gait and motor cortex organization: implications for a rodent model of cerebral palsy. Neuroscience 129, 141-156.), CP-like movement disorders were more reliably reproduced in rats by hind limb sensorimotor restriction (disuse) during development rather than perinatal asphyxia (PA). To gain new insights into the underpinning mechanisms of CP symptoms we investigated the long-term effects of PA and disuse on the hind limb musculoskeletal histology and topographical organization in the primary somatosensory cortex (S1) of adult rats. Developmental disuse (i.e. hind limb immobilization) associated with PA induced muscle fiber atrophy, extracellular matrix changes in the muscle, and mild to moderate ankle and knee joint degeneration at levels greater than disuse alone. Sensorimotor restricted rats with or without PA exhibited a topographical disorganization of the S1 cortical hind limb representation with abnormally large, multiple and overlapping receptive fields. This disorganization was enhanced when disuse and PA were associated. Altered cortical neuronal properties included increased cortical responsiveness and a decrease in neuronal selectivity to afferent inputs. These data support previous observations that asphyxia per se can generate the substrate for peripheral tissue and brain damage, which are worsened by aberrant sensorimotor experience during maturation, and could explain the disabling movement disorders observed in children with CP. |
| Databáze: | OpenAIRE |
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