Effects of hydroxyflutamide on rats treated with a superovulatory dose of pregnant mare serum gonadotropin
| Autor: | Basil Ho Yuen, Frank H. Yu, Young S. Moon, Young W. Yun |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Ovulation
medicine.medical_specialty Gonadotropins Equine Physiology medicine.drug_class media_common.quotation_subject Pregnant Mare Serum Gonadotropin Antiandrogen chemistry.chemical_compound Organ Culture Techniques Physiology (medical) Internal medicine medicine Animals Androstenedione Chromatography High Pressure Liquid Progesterone Testosterone media_common Pharmacology Estradiol Ovary Rats Inbred Strains General Medicine Androgen Flutamide Rats Endocrinology chemistry Pregnenolone Androgens Oocytes Female Hydroxyflutamide medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 69:185-190 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y91-027 |
| Popis: | Immature female rats treated with superovulatory doses of pregnant mare serum gonadotropin (PMSG) were used to study the effects of the antiandrogen hydroxyflutamide on steroid production, particularly the biologically active androgens, in two experiments. In the first experiment, animals were given either 5 mg hydroxyflutamide or vehicle alone at 30 and 36 h following 40 IU PMSG. Compared with the vehicle group, hydroxyflutamide treatment significantly reduced the percentage of degenerate oocytes recovered from oviducts (p −5 M) and (or) testosterone (10−7 M) to study [4-14C]pregnenolone metabolism to major steroids. In 40 IU stimulated ovaries, hydroxyflutamide significantly decreased the metabolism of pregnenolone to progesterone (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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