Serum relaxin level predicts recurrence of atrial fibrillation after radiofrequency catheter ablation
| Autor: | Weijian Huang, Lingzhi Chen, Lingyue Sun, Changxi Chen, Hao Zhou, Xiang Qu, Zhan Gao |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Kaplan-Meier Estimate 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Recurrence Risk Factors Internal medicine Atrial Fibrillation medicine Humans Sinus rhythm 030212 general & internal medicine Prospective Studies Aged Proportional Hazards Models Relaxin Aged 80 and over business.industry Proportional hazards model Hazard ratio Atrial fibrillation Middle Aged medicine.disease Confidence interval Cardiac surgery Treatment Outcome ROC Curve Heart failure Multivariate Analysis Cardiology Catheter Ablation Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart and vessels. 34(9) |
| ISSN: | 1615-2573 |
| Popis: | Relaxin, an emerging biomarker in heart failure, is involved in fibrosis and inflammation. The value of relaxin in predicting recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) is unknown and the subject of this study. We prospectively enrolled 248 consecutive patients with AF (paroxysmal in 127 and persistent in 121) who underwent RFCA at our center after measurement of circulating levels of relaxin by ELISA. Kaplan–Meier analysis with log-rank test and multivariate analysis were used to assess the association between pre-RFCA relaxin levels and post-RFCA AF recurrence at 18 months follow-up. At mean 16.3 ± 3.8 months post-RFCA, 195 (78.6%) patients maintained sinus rhythm, and their pre-RFCA relaxin level was lower than that in patients with AF recurrence (P |
| Databáze: | OpenAIRE |
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