The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study
| Autor: | D. Giebner, Eileen Beckman, A. Galster, T. Williams, G. Bloomquist, Erin Frank, K. Woods, C. Tigges, Lisa Steele, V. Patel, Michael C. Spaeder, Alexandra L. Hanlon, Kate G. Ackerman, J. Ascani, Sharon Y. Irving, Tammy Uhl, Steven L. Shein, Bridget Daly, T. Wilson, S. Wrenn, M. Dumis-trascu, M. Villar, Vijay Srinivasan, D. Jarvis, Janet R. Hume, Julie C. Fitzgerald, Denise M. Goodman, T. Monjure, J. Deschenes, G. Krahn, Judy Verger, Frank A. Maffei, Kelli Howard, Ann Thompson, Marisa Tucci, Dai Kimura, Heather K. Chandler, H. Anthony, Shirley Viteri, Sholeen Nett, A. Orioles, C. Rodriguez, K. Typpo, Michael T. Bigham, Ira M. Cheifetz, Neal J. Thomas, Patricia S. Fontela, Laura Campbell, Melissa Evans, Kate Madden, K. Murkowski, Felice Su, E. Bezares, Samir S. Shah, Katri V. Typpo, N. Rizkalla, S. Valley, A. Puig-Ramos, Ronald C. Sanders, G. Puig, LeeAnn M. Christie, S. Latifi, Christopher L. Carroll, B. Markowitz, Renee A. Higgerson, Glenda Hefley, R. Morzov, K. Kypuros, S. Gertz, Kris Bysani, Aileen Kirby, A. Doucette, L. Linnerud, Balagangadhar R. Totapally, Jennifer McArthur, Peter Skippen, Lauren R. Sorce, T. Polanski, Yong Yun Han, Andrew D. McInnes, Madhuradhar Chegondi, Ann-Marie Brown, Derek S. Wheeler, Kyle J Rehder, Carleen Zebuhr, Constantine Dimitriades, Scott L. Weiss, Matthew Sharron, K. Wolfe, Ricardo L. Garcia, Kelly Michelson, Vinay M. Nadkarni, S. Layburn, J. Frazier, J. Terry, C. Barlow, Andrew T. Costarino, E. Zielinski, A. Hughes-Schalk |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Asia Adolescent Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Nutritional Status Comorbidity macromolecular substances Critical Care and Intensive Care Medicine Intensive Care Units Pediatric Risk Assessment Severity of Illness Index Article Body Mass Index Sepsis 03 medical and health sciences 0302 clinical medicine Overnutrition Internal medicine Severity of illness medicine Prevalence Humans 030212 general & internal medicine Child business.industry Septic shock Malnutrition 030208 emergency & critical care medicine Odds ratio South America medicine.disease Europe Child Preschool North America Female business Body mass index |
| Zdroj: | Critical Care Medicine, 46, 11, pp. e1029-e1039 Critical Care Medicine, 46, e1029-e1039 |
| ISSN: | 0090-3493 |
| Popis: | Contains fulltext : 200437.pdf (Publisher’s version ) (Closed access) OBJECTIVES: The impact of nutrition status on outcomes in pediatric severe sepsis is unclear. We studied the association of nutrition status (expressed as body mass index z score) with outcomes in pediatric severe sepsis. DESIGN: Secondary analysis of the Sepsis Prevalence, Outcomes, and Therapies study. Patient characteristics, ICU interventions, and outcomes were compared across nutrition status categories (expressed as age- and sex-adjusted body mass index z scores using World Health Organization standards). Multivariable regression models were developed to determine adjusted differences in all-cause ICU mortality and ICU length of stay by nutrition status. SETTING: One-hundred twenty-eight PICUs across 26 countries. PATIENTS: Children less than 18 years with severe sepsis enrolled in the Sepsis Prevalence, Outcomes, and Therapies study (n = 567). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Nutrition status data were available for 417 patients. Severe undernutrition was seen in Europe (25%), Asia (20%), South Africa (17%), and South America (10%), with severe overnutrition seen in Australia/New Zealand (17%) and North America (14%). Severe undernutrition was independently associated with all-cause ICU mortality (adjusted odds ratio, 3.0; 95% CI, 1.2-7.7; p = 0.02), whereas severe overnutrition in survivors was independently associated with longer ICU length of stay (1.6 d; p = 0.01). CONCLUSIONS: There is considerable variation in nutrition status for children with severe sepsis treated across this selected network of PICUs from different geographic regions. Severe undernutrition was independently associated with higher all-cause ICU mortality in children with severe sepsis. Severe overnutrition was independently associated with greater ICU length of stay in childhood survivors of severe sepsis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|