Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods
| Autor: | Ioanna Prapa, Vasiliki Kompoura, Amalia E. Yanni, Maria Antoniadou, Eugenia Bezirtzoglou, Yiannis Kourkoutas, Valentini Santarmaki, Theodoros Varzakas, Konstantina Kantartzi, Christina Tsigalou, Gregoria Mitropoulou, C. Voidarou, Elisavet Stavropoulou |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) gut microbiome 030209 endocrinology & metabolism Disease Review Gut flora fermented foods Microbiology 03 medical and health sciences 0302 clinical medicine Immune system Functional food Virology Diabetes mellitus Flora (microbiology) Medicine digestive health lcsh:QH301-705.5 functional foods biology diabetes business.industry medicine.disease biology.organism_classification Gut microbiome 030104 developmental biology nutrition probiotics lcsh:Biology (General) Immunology Animal studies business prebiotics |
| Zdroj: | Microorganisms, Vol 9, Iss 516, p 516 (2021) Microorganisms |
| ISSN: | 2076-2607 |
| Popis: | Over the last decades, the incidence of diabetes has increased in developed countries and beyond the genetic impact, environmental factors, which can trigger the activation of the gut immune system, seem to affect the induction of the disease process. Since the composition of the gut microbiome might disturb the normal interaction with the immune system and contribute to altered immune responses, the restoration of normal microbiota composition constitutes a new target for the prevention and treatment of diabetes. Thus, the interaction of gut microbiome and diabetes, focusing on mechanisms connecting gut microbiota with the occurrence of the disorder, is discussed in the present review. Finally, the challenge of functional food diet on maintaining intestinal health and microbial flora diversity and functionality, as a potential tool for the onset inhibition and management of the disease, is highlighted by reporting key animal studies and clinical trials. Early onset of the disease in the oral cavity is an important factor for the incorporation of a functional food diet in daily routine. |
| Databáze: | OpenAIRE |
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