Metal-Metal Hip Prosthesis and Kidney Cancer: Assumed Role of Chromium and Cobalt Overload
| Autor: | Valentin Massardier, Ana-Maria Trunfio-Sfarghiu, Jacques Hubert, Michel Vincent, Mickaël Catinon |
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| Přispěvatelé: | Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne] (LaMCoS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2020 |
| Předmět: |
Chromium
Nephrology medicine.medical_specialty Arthroplasty Replacement Hip [SDV]Life Sciences [q-bio] medicine.medical_treatment Metal Nanoparticles Prosthesis Design Prosthesis Internal medicine medicine Humans Blood test radiotherapy Specialty: Neurology [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] discomfort Medication: -Clinical Procedure: Cancer nodule removal Orthopedics and Traumatology Hip Prosthesis 68-year-old Final Diagnosis: Bilateral renal carcinoma Symptoms: Bleeding of renal track Kidney Nephrology Authors' Contribution: Study Design A Data Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G medicine.diagnostic_test business.industry Articles Cobalt General Medicine Middle Aged medicine.disease Arthroplasty Kidney Neoplasms Prosthesis Failure 3. Good health Surgery prosthesis replacement medicine.anatomical_structure Orthopedic surgery Female Hip Prosthesis Implant business Kidney cancer |
| Zdroj: | The American journal of case reports The American journal of case reports, 2020, ⟨10.12659/AJCR.923416⟩ The American Journal of Case Reports |
| ISSN: | 1941-5923 |
| DOI: | 10.12659/ajcr.923416 |
| Popis: | Patient: Female, 68-year-old Final Diagnosis: Bilateral renal carcinoma Symptoms: Bleeding of renal track • discomfort Medication: — Clinical Procedure: Cancer nodule removal • prosthesis replacement • radiotherapy Specialty: Neurology • Orthopedics and Traumatology Objective: Unusual clinical course Background: The case of a patient with bilateral renal cancers diagnosed at 94 and 120 months after metal-on-metal hip placement may serve as a warning. It suggests that there may be a need for kidney echography observation of patients with similar types of prostheses. Case Report: A 61-year-old woman received a metal-on-metal hip prosthesis for degenerative arthritis in January 2007. In November 2014, after bleeding from the renal tract, she was diagnosed with clear cell carcinoma of the right kidney. When she returned to her orthopaedic surgeon 1 year later, a blood test showed a serum cobalt level that exceeded the French medical agency recommendation. After the patient’s metallic acetabulum was replaced in September 2015, her blood cobalt level fell. However, in February 2017, she was diagnosed with adenocarcinoma of the left kidney. Laser-induced breakdown spectroscopy (LIBS) showed cobalt, chromium, and silica overload in both the patient’s kidneys despite the drop in serum levels. Conclusions: In this case, exposure to a cobalt-chromium implant with high particulate wear, LIBS results showing chromium overload of the kidneys, diagnosis of renal cancer at 7 years, 10 months and 10 years in a patient with a metal-on-metal hip prosthesis suggests that there may be a causal relationship between the implant, carcinogenic chromium intoxication, and development of renal cancer. |
| Databáze: | OpenAIRE |
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