Dopamine and serotonin inhibition of neurite elongation of different identified neurons
| Autor: | S. B. Kater, Philip G. Haydon, D. P. McCobb |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Helisoma
Neurons Serotonin biology Neurite Dopamine Snails Motility biology.organism_classification Axons Cell biology Nerve Regeneration Cellular and Molecular Neuroscience chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Animals Neuron Growth cone Neurotransmitter Neuroscience medicine.drug |
| Zdroj: | Journal of neuroscience research. 19(1) |
| ISSN: | 0360-4012 |
| Popis: | This study demonstrates that a second classical neurotransmitter, dopamine, can act to suppress regenerative neurite outgrowth. Single identified neurons were dissected from two central ganglia of the snail Helisoma, and growth cone motility was studied as neurites regenerated in cell culture. Both dopamine and serotonin inhibited growth cone motility and elongation of neurites. Outgrowth inhibition ranged from sustained arrest to a similar but transient response. The effects of dopamine and serotonin are neuron-selective. Specific neurons affected by dopamine and serotonin represent distinct sets. One neuron was found that responds to both agents. The implications of neurotransmitter regulation of the dynamics of neuronal morphology are discussed. |
| Databáze: | OpenAIRE |
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