A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas)
| Autor: | Emilie Réalis-Doyelle, Lorane Le Franc, Julie Schwartz, Pascal Favrel |
|---|---|
| Přispěvatelé: | Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Osmotic stress
Salinity Oyster Mollusk Dopamine [SDV]Life Sciences [q-bio] Lophotrochozoa Applied Microbiology and Biotechnology Receptors Dopamine 03 medical and health sciences 0302 clinical medicine biology.animal medicine Animals Crassostrea Gonads Receptor 030304 developmental biology 0303 health sciences biology Dop2/INDR Reproduction Dopaminergic Pacific oyster biology.organism_classification Cell biology Tyramine receptor Gene Expression Regulation Dopamine receptor Female Signal transduction 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Marine Biotechnology Marine Biotechnology, Springer Verlag, 2021, ⟨10.1007/s10126-021-10052-5⟩ Marine Biotechnology, 2021, ⟨10.1007/s10126-021-10052-5⟩ |
| ISSN: | 1436-2228 1436-2236 |
| DOI: | 10.1007/s10126-021-10052-5⟩ |
| Popis: | International audience; The dopaminergic signaling pathway is involved in many physiological functions in vertebrates, but poorly documented in protostome species except arthropods. We functionally characterized a novel dopamine receptor in the Pacific oyster (Crassostrea gigas), activated by dopamine and tyramine with different efficacy and potency orders. This receptor-Cragi-DOP2R-belongs to the D 1-like family of receptors and corresponds to the first representative of the Dop2/invertebratetype dopamine receptor (Dop2/INDR) group ever identified in Lophotrochozoa. Cragi-DOP2R transcripts were expressed in various adult tissues, with higher expression levels in the visceral ganglia and the gills. Following an experiment under acute osmotic conditions, Cragi-DOP2R transcripts significantly increased in the visceral ganglia and decreased in the gills, suggesting a role of dopamine signaling in the mediation of osmotic stress. Furthermore, a role of the Cragi-DOP2R signaling pathway in female gametogenesis and in early oyster development was strongly suggested by the significantly higher levels of receptor transcripts in mature female gonads and in the early embryonic stages. |
| Databáze: | OpenAIRE |
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