Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure
| Autor: | Axel Linke, Gerhard Schuler, Sandra Erbs, Volker Adams, P. Christian Schulze, Nina Schoene, Juergen Kratzsch, S Moebius-Winkler, Stephan Gielen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Leptin
Male medicine.medical_specialty Statistics as Topic Myocardial Ischemia Inflammation Receptors Cell Surface Exercise intolerance Blood Sedimentation Severity of Illness Index Body Mass Index Oxygen Consumption Internal medicine medicine Humans cardiovascular diseases Aged Heart Failure Ejection fraction Leptin receptor Exercise Tolerance business.industry Tumor Necrosis Factor-alpha VO2 max Stroke Volume Stroke volume Middle Aged medicine.disease Endocrinology Solubility Heart failure Case-Control Studies Chronic Disease cardiovascular system Exercise Test Cytokines Receptors Leptin medicine.symptom Inflammation Mediators Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | European journal of heart failure. 5(1) |
| ISSN: | 1388-9842 |
| Popis: | Patients with chronic heart failure (CHF) have metabolic abnormalities, leading to a catabolic syndrome, with progressive loss of skeletal muscle in advanced stages of the disease. Leptin, the product of an obesity gene, has been associated with energy expenditure and weight regulation. The aim of this study was to assess serum levels of leptin and its soluble receptor in relation to exercise intolerance and neurohumoral activation in patients with CHF. We investigated 53 patients with CHF left ventricular ejection fraction (LVEF) 25+/-1%, age 56.6+/-1.3 years, Maximal oxygen uptake (VO(2) max) 16.3+/-0.6 ml/min.kg) sub-classified according to peak oxygen consumption oforor=14 ml/min.kg and 11 age-matched controls (LVEF 70+/-1, age 60.5+/-4.0 years, (VO(2)max) 26.9+/-1.6 ml/min.kg). Body mass index-adjusted serum levels of leptin and soluble leptin receptor were increased in patients with CHF compared to the controls (0.28+/-0.03 vs. 0.22+/-0.04 ng.m(2)/ml.kg and 32.6+/-1.9 ng/ml vs. 22.9+/-2.3, P0.05). This increase was even more pronounced in patients with CHF and severe exercise intolerance (0.43+/-0.08 vs. 0.21+/-0.02 and 0.22+/-0.04 ng.m(2)/ml.kg; P0.01 vs. VO(2)max14 ml/min.kg and controls). Elevated levels of leptin correlated with an increased serum concentration of TNFalpha (r=0.749, P0.01) in this subgroup of patients with CHF. We conclude that patients with advanced CHF show elevated serum levels of leptin and its soluble receptor. This finding indicates that leptin may participate in the catabolic state leading to the development of cardiac cachexia in the course of CHF. |
| Databáze: | OpenAIRE |
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