Protective Effect ofPistacia lentiscusOil Against Bleomycin-Induced Lung Fibrosis and Oxidative Stress in Rat
| Autor: | Saloua Ben Khamsa, Anouar Abidi, Hichem Sebai, Nadia Kourda, Nadhem Aissani, Raja Serairi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Cancer Research Antioxidant Pulmonary Fibrosis medicine.medical_treatment Medicine (miscellaneous) Pharmacology Protective Agents medicine.disease_cause Bleomycin Antioxidants Lipid peroxidation Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fibrosis Pulmonary fibrosis medicine Animals Plant Oils Rats Wistar Lung Nutrition and Dietetics Pistacia biology Superoxide Dismutase Chemistry Fatty Acids Organ Size respiratory system Catalase medicine.disease biology.organism_classification Rats respiratory tract diseases Oxidative Stress 030104 developmental biology Oncology 030220 oncology & carcinogenesis biology.protein Lipid Peroxidation Oxidative stress |
| Zdroj: | Nutrition and Cancer. 69:490-497 |
| ISSN: | 1532-7914 0163-5581 |
| Popis: | We aimed in the present study to investigate the protective effect of Pistacia lentiscus oil against bleomycin-induced lung fibrosis as well as the involvement of oxidative stress in such protection. In this respect, adult male Wistar rats were used and divided into three groups of twenty each: control (NaCl, 0.9%), bleomycin, and bleomycin (4 mg/kg b.w.) + P. lentiscus oil (3 g/kg, b.w.). Animals were pretreated for 30 days before the induction of fibrosis by bleomycin and 1 wk after the induction of fibrosis. The oil principal compounds detected by gas chromatography analysis are: Linoleic and palmitic acids (70.6 and 24.7%, respectively). Our data demonstrated that P. lentiscus oil protected against bleomycin-induced fibrosis as evidenced by TGFβ immunostaining increase in lungs fibrocytes as well as inflammatory infiltrate. We also showed that acute bleomycin-induced fibrosis was accompanied by an oxidative stress in lung tissue as assessed by an increase of lipid peroxidation as well as antioxidant enzyme activities depletion such as superoxide dismutase (SOD) and catalase (CAT). More importantly, P. lentiscus oil treatment reversed all bleomycin-induced oxidative stress parameters disturbances. In conclusion, we suggest that P. lentiscus oil had potent protective effects against bleomycin-induced fibrosis due in part to its antioxidant properties. |
| Databáze: | OpenAIRE |
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