Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in C57bl/6 Models
| Autor: | Maria Lígia Rodrigues Macedo, Elisvânia Freitas dos Santos, Leonardo Recena Aydos, Ana Cristina Jacobowski, Luane Aparecida do Amaral, Roberta Serafim de Souza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
C57BL/6 nonalcoholic fatty liver disease Taste obesity Physiology Review Diet High-Fat Oral gavage 03 medical and health sciences Mice 0302 clinical medicine Non-alcoholic Fatty Liver Disease NAFLD Nonalcoholic fatty liver disease medicine Ingestion Animals C57BL mice Nutrition and Dietetics biology business.industry High fat diet biology.organism_classification medicine.disease Lipid Metabolism Obesity Lipids Mice Inbred C57BL Disease Models Animal 030104 developmental biology high-fat diet Liver 030211 gastroenterology & hepatology Treatment time business Food Science |
| Zdroj: | Nutrients |
| ISSN: | 2072-6643 |
| Popis: | Researchers have a range of animal models in which to study Nonalcoholic fatty liver disease (NAFLD). Induction of NAFLD by a high-fat diet in the C57BL/6 strain is the most widely used among mice. In this study, we review works that performed NAFLD induction by a high-fat diet using the C57BL/6 strain, focusing on experiments on the effects of lipid ingestion. Studies are initially distinguished into researches in which mice received lipids by oral gavage and studies in which lipid was added to the diet, and each of these designs has peculiarities that must be considered. Oral gavage can be stressful for animals and needs trained handlers but allows accurate control of the dose administered. The addition of oils to the diet can prevent stress caused to mice by gavage, but possible changes in the consistency, taste, and smell of the diet should be considered. Regarding the experimental design, some variables, such as animal sex, treatment time, and diet-related variables, appear to have a definite pattern. However, no pattern was found regarding the number of animals per group, age at the beginning of the experiment, time of adaptation, the substance used as a vehicle, and substance used as a control. |
| Databáze: | OpenAIRE |
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