Efficacy of Modified Human Immune Serum Globulin in the Treatment of Experimental Murine Infections with Seven Immunotypes of Pseudomonas aeruginosa
| Autor: | Starkey D. Davis |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.drug_class Antibiotics Biology medicine.disease_cause Microbiology Mice Pseudomonas infection Agglutination Tests medicine Animals Humans Immunology and Allergy Pseudomonas Infections Opsonin Pseudomonas aeruginosa Immune Sera medicine.disease Effective dose (pharmacology) Agglutination (biology) Infectious Diseases Injections Intravenous Immunology Tobramycin biology.protein Serum Globulins Peritoneum Antitoxin Antibody |
| Zdroj: | Journal of Infectious Diseases. 131:717-721 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/131.6.717 |
| Popis: | Modified immune serum globulin, prepared from human immune serum globulin by a nonenzymatic method, is apparently safe for intravenous administration to humans. The efficacy of the preparation was determined in experimental murine infections with seven immunotypes of Pseudomonas aeruginosa. Intravenously administered 0.85% NaCI, 0.3 M glycine, and 10% human albumin did not protect against lethal pseudomonas infection, whereas modified immune serum globulin given by the same route did protect mice. In the mouse protection test, the mean dose of the preparation that saved 50% of mice infected with any of eight strains of P. aeruginosa was 480 mg/kg (range, 12-2,333 mg/kg). For five strains the 50% effective dose was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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