A comparison of three vitamin a dosing regimens in extremely-low-birth-weight infants
| Autor: | Namasivayam Ambalavanan, Waldemar A. Carlo, Claire Roane, Jon E. Tyson, Tzong-Jin Wu, Kathleen A. Kennedy |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Pediatrics Birth weight Infant Premature Diseases Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans Infant Very Low Birth Weight Vitamin A Bronchopulmonary Dysplasia business.industry Infant Newborn Retinol Gestational age medicine.disease Retinol-Binding Proteins Regimen Low birth weight Retinol binding protein chemistry Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Female medicine.symptom business Infant Premature |
| Zdroj: | The Journal of Pediatrics. 142:656-661 |
| ISSN: | 0022-3476 |
| DOI: | 10.1067/mpd.2003.214 |
| Popis: | Objective Vitamin A supplementation reduces bronchopulmonary dysplasia (BPD)/death in extremely low birth weight neonates. It was hypothesized that compared with the standard regimen of 5000 IU 3 times per week for 4 weeks, (1) a higher dose (10,000 IU 3 × per week) would increase serum retinol and retinol binding protein (RBP) and lower relative dose responses (RDR), and (2) once-per-week dosing (15,000 IU once per week) would lead to equivalent levels, RBP, and RDR. Study design Extremely low birth weight neonates (n = 120) receiving O2/mechanical ventilation at 24 hours were randomly assigned to (1) standard, (2) higher dose, or (3) once-per-week regimens. Measures of vitamin A deficiency were serum retinol 10% on day 28. BPD was defined as O2/mechanical ventilation at 36 weeks' postmenstrual age. Results Groups were similar at enrollment (median gestational age, 25 weeks; birth weight, 689 g). Possible toxicity was seen in |
| Databáze: | OpenAIRE |
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