Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities
| Autor: | Maria B. Cassera, Ana Lisa Valenciano, Rolly G. Fuentes, Andriamalala Rakotondrafara, T. Daniel Crawford, Yongle Du, Kirk C. Pearce, David G. I. Kingston, Vincent E. Rasamison |
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| Rok vydání: | 2018 |
| Předmět: |
Stereochemistry
Plasmodium falciparum Pharmaceutical Science Growth inhibitory Phloroglucinol Plant Roots 01 natural sciences Article Analytical Chemistry Antimalarials chemistry.chemical_compound Triterpenoid Cell Line Tumor Drug Discovery Humans Garcinia IC50 Cell Proliferation Pharmacology Ethanol Molecular Structure biology Plant Extracts 010405 organic chemistry Chemistry Organic Chemistry Absolute configuration biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Plant species Molecular Medicine Tocotrienol |
| Zdroj: | Journal of Natural Products. 82:431-439 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.8b00379 |
| Popis: | Garcinia dauphinensis is a previously uninvestigated endemic plant species of Madagascar. The new phloroglucinols dauphinols A-F and 3'-methylhyperjovoinol B (1-7) and six known phloroglucinols (8-13) together with tocotrienol 14 and three triterpenoids 15-17 were isolated from an ethanolic extract of G. dauphinensis roots using various chromatographic techniques. The structures of the isolated compounds were elucidated by NMR, MS, optical rotation, and ECD data. Theoretical ECD spectra and specific rotations for 2 were calculated and compared to experimental data in order to assign its absolute configuration. Among the compounds tested, 1 showed the most promising growth inhibitory activity against A2870 ovarian cancer cells, with IC(50) = 4.5 ± 0.9 μM, while 2 had good antiplasmodial activity against the Dd2 drug-resistant strain of Plasmodium falciparum, with IC(50) = 0.8 ± 0.1 μM. |
| Databáze: | OpenAIRE |
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