Tailoring the self-assembly of a tripeptide for the formation of antimicrobial surfaces
| Autor: | Meital Reches, Deborah E. Shalev, Tal Zada, Carlos Alemán, Sivan Nir, Omer Agazani, David Zanuy |
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| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies |
| Rok vydání: | 2019 |
| Předmět: |
Superfícies (Tecnologia)
Biofouling Surface Properties Supramolecular chemistry Surfaces (Technology) Portable water purification Peptide 02 engineering and technology Tripeptide Molecular dynamics Molecular Dynamics Simulation 010402 general chemistry 01 natural sciences Bacteris chemistry.chemical_compound Glucose Oxidase Anti-Infective Agents Nanotechnology General Materials Science Dinàmica molecular Nuclear Magnetic Resonance Biomolecular chemistry.chemical_classification Drug Carriers Bacteria Nanotecnologia Enginyeria biomèdica [Àrees temàtiques de la UPC] Biofilm 021001 nanoscience & nanotechnology Enzymes Immobilized Combinatorial chemistry 0104 chemical sciences Food packaging Monomer chemistry Biofilms Pèptids 0210 nano-technology Peptides Oligopeptides |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) |
| ISSN: | 2040-3372 |
| Popis: | The accumulation of bacteria on surfaces is currently one of the greatest concerns f or the supply of proper health, water and energy. Here, we describe the mechanism by which a single peptide forms two pH-dependent supramolecular particles that resist bacterial contamination. By using NMR and molecular dynamics ( MD), we determined the structures of the peptide monomers and showed the forces directing the self-assembly of each structure under different conditions. These peptide assemblies change the characteristics of bare gla s and confer it with the ability to prevent biofilm formation. Furthermore, they can adsorb and re ease active compounds as demonstrated with an anticancer drug, antibiotic and enzyme. This synergism and the detailed understanding of the proces ses are necessary for developing new sterile surfaces for health-care systems, water puri ication devices, food packaging or any environment that suffers from biocontamination. |
| Databáze: | OpenAIRE |
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