Synthesis and biological evaluation of mannose-6-phosphate-coated multivalent dendritic cluster glycosides

Autor: O Srinivas, Siva Kumar Nadimpalli, Narayanaswamy Jayaraman, Narasimha Murthy Bandaru, S. Radhika
Rok vydání: 2005
Předmět:
Zdroj: Organic & Biomolecular Chemistry. 3:4252
ISSN: 1477-0539
1477-0520
DOI: 10.1039/b506348e
Popis: The synthesis of multivalent dendritic cluster glycosides of mannopyranosyl-6-phosphate is presented. Poly(amido amine)-based dendrimers of 0.5-3.5 generations, containing carboxylic acid peripheral functionalities, were utilized so as to install 4, 8, 16 and 32 mannopyranosyl-6-phosphate residues at the peripheries of the dendrimers. Amide bond formation between an amine-tethered mannopyranosyl-6-phosphate monomer unit and carboxylic acid-functionalized dendrimers was conducted to synthesize the dendritic cluster glycosides. The constitutions of the Man-6-P-containing dendrimers were assessed by 1H, 13C and 31P NMR spectroscopies and the sugar content analysis by a resorcinol assay. Preliminary biological studies with few newly synthesized Man-6-P-containing dendrimers showed that these compounds could bind the purified goat liver mannose 6-phosphate receptor (MPR 300) protein.
Databáze: OpenAIRE