Effect of Alpha-Chymotrypsin on Corneal Wound Healing
| Autor: | Howard N. Bernstein, Austin I. Fink, Dick Binkhorst |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Wound Healing
medicine.medical_specialty Zonular fibers business.industry Forceps Proteolytic enzymes Alpha-chymotrypsin eye diseases Surgery Cornea Ophthalmology medicine.anatomical_structure Corneal wound medicine Chymotrypsin Humans sense organs Nictitating membrane business Wound healing Corneal Injuries |
| Zdroj: | Archives of Ophthalmology. 64:104-107 |
| ISSN: | 0003-9950 |
| DOI: | 10.1001/archopht.1960.01840010106009 |
| Popis: | The use of α-chymotrypsin to facilitate intracapsular cataract extraction has aroused widespread interest in the possibilities for enzymatic zonulolysis. Barraquer's1,2initial reports have been very encouraging and seem to justify the use of this proteolytic enzyme. The effect of this drug appears to be selective for lysing the zonular fibers of the crystalline lens. A recent editorial,3however, reported three cases of delayed wound closure following the use of α-chymotrypsin. The wide acceptance of this enzyme suggested a need to clarify this possible disadvantage. It seemed desirable, therefore, to undertake such a study. Method Cats ranging from 3.0 to 4.5 kg. in weight were used as the experimental animals. The surgical procedure for the control and experimental groups was identical. The nictitating membrane of the eye to be operated was grasped with a toothed forceps and a traction suture placed through it. The maneuver permitted more adequate exposure |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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