Increased post-induction intensification improves outcome in children and adolescents with a markedly elevated white blood cell count (≥200 × 109/l) with T cell acute lymphoblastic leukaemia but not B cell disease: a report from the Children's Oncology Gr
| Autor: | Harland Sather, Xiaomin Lu, James B. Nachman, Caroline A. Hastings, Meenakshi Devidas, Paul S. Gaynon, Nita L. Seibel |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Leukocytosis Kaplan-Meier Estimate Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Gastroenterology Leukocyte Count Prednisone hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols Medicine Child Remission Induction Hematology Treatment Outcome medicine.anatomical_structure Vincristine Child Preschool Population study Female medicine.symptom circulatory and respiratory physiology medicine.drug Risk medicine.medical_specialty Adolescent Cyclophosphamide Disease-Free Survival Article Internal medicine White blood cell Leukemia B-Cell Asparaginase Humans B cell Dose-Response Relationship Drug business.industry Daunorubicin Infant Cancer medicine.disease Doxorubicin Immunology Cranial Irradiation Idarubicin business Follow-Up Studies |
| Zdroj: | British Journal of Haematology. 168:533-546 |
| ISSN: | 0007-1048 |
| DOI: | 10.1111/bjh.13160 |
| Popis: | Summary Children and adolescents presenting with a markedly elevated white blood cell (ME WBC) count (WBC ≥200 × 109/l) comprise a unique subset of high-risk patients with acute lymphoblastic leukaemia (ALL). We evaluated the outcomes of the 251 patients (12% of the study population) with ME WBC treated on the Children's Cancer Group-1961 protocol. Patients were evaluated for early response to treatment by bone marrow morphology; those with a rapid early response were randomized to treatment regimens testing longer and stronger post-induction therapy. We found that ME WBC patients have a poorer outcome compared to those patients presenting with a WBC |
| Databáze: | OpenAIRE |
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