Plasma levels of chlorodesmethyldiazepam in humans

Autor:	L. Dal Bo, A. Castellani, E. Mussini, D. Perbellini, F. Marcucci, P. Fresia
Rok vydání:	1980
Předmět:	Pharmacology Adult Male Chromatography Diazepam Time Factors Chemistry Extraction (chemistry) Nordazepam Pharmaceutical Science Administration Oral General Medicine Plasma Plasma levels chemistry.chemical_compound Benzodiazepines Peak plasma Anti-Anxiety Agents Plasma concentration Humans Pharmacology (medical) Centrifugation Benzene Biotransformation
Zdroj:	Biopharmaceuticsdrug disposition. 1(3)
ISSN:	0142-2782
Popis:	Chlorodesmethyldiazepam (I) concentrations were followed for 72 h in the plasma of four volunteers given 2 mg of the drug orally. The drug appears to be well absorbed, reaching peak plasma levels of 20–30 ng ml−1 1–2 h after administration; 72 h after administration, plasma concentrations are still measurable (5 ng ml−1). The analytical method involved a single extraction of I from the plasma into benzene followed by centrifugation, evaporation, and gas-chromatographic analysis of the samples.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6df3a6d868d65ed4481090460e58617 https://pubmed.ncbi.nlm.nih.gov/6778522 Zobrazit plný text záznamu Plný text