Cardiovascular Benefit of Magnitude of Low-Density Lipoprotein Cholesterol Reduction
| Autor: | Catherine Rahilly-Tierney, Elizabeth V. Lawler, J. Michael Gaziano, Richard E. Scranton |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Blood lipids Cohort Studies Risk Factors Physiology (medical) Internal medicine Humans Medicine Myocardial infarction Aged Retrospective Studies Aged 80 and over biology business.industry Proportional hazards model Anticholesteremic Agents Hazard ratio Age Factors Retrospective cohort study Cholesterol LDL Lipoprotein(a) Middle Aged medicine.disease United States Surgery United States Department of Veterans Affairs Quartile Cardiovascular Diseases biology.protein Cardiology Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Circulation. 120:1491-1497 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.108.846931 |
| Popis: | Background— We examined the effect of the magnitude of low-density lipoprotein cholesterol (LDL-C) reduction across subjects of various ages in a retrospective cohort study. Methods and Results— We selected 20 132 male veterans at high risk for an acute cardiovascular event and who had 2 or more LDL-C measurements before their first documented acute myocardial infarction, revascularization, death, or censoring date. LDL-C reduction was categorized as no reduction ( Conclusions— In a cohort of veterans at high risk for cardiovascular events, patients of all ages, including those 80 years or older, benefitted the most from large reductions in LDL-C. |
| Databáze: | OpenAIRE |
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