Efflux transporters of the human placenta
| Autor: | Courtni E Allen, Amber M. Young, Kenneth L. Audus |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Placenta
Pharmaceutical Science Biological Transport Active Pharmacology Bile Acids and Salts Fetal membrane Pregnancy medicine ATP Binding Cassette Transporter Subfamily G Member 2 Humans ATP Binding Cassette Transporter Subfamily B Member 1 Maternal-Fetal Exchange P-glycoprotein Fetus Membrane Glycoproteins biology Hydroxysteroid Dehydrogenases Transporter medicine.disease Drug Resistance Multiple Neoplasm Proteins medicine.anatomical_structure Biochemistry biology.protein ATP-Binding Cassette Transporters Female Multidrug Resistance-Associated Proteins Carrier Proteins Hormone |
| Zdroj: | Advanced drug delivery reviews. 55(1) |
| ISSN: | 0169-409X |
| Popis: | The use of pharmaceuticals during pregnancy is often a necessity for the health of the mother. Until recently, the placenta was viewed as a passive organ through which molecules are passed indiscriminately between mother and fetus. In reality, the placenta contains a plethora of transporters, some of which appear to be specifically dedicated to removal of xenobiotics and toxic endogenous compounds. Drug efflux transporters such as P-glycoprotein (P-gp), several multidrug resistant associated proteins (MRPs) and breast cancer resistant protein (BCRP) may provide mechanisms that protect the developing fetus. Bile acid transporters may also play a role in exporting compounds back into the maternal compartment. Steroid hormones directly influence the level of expression and function in some of these transporters. Investigating the link between the hormones of pregnancy and these drug efflux transporters is one possible key in developing strategies to deliver drugs to the mother with minimal fetal risk. |
| Databáze: | OpenAIRE |
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