Incidence and Outcome of Uveitic Glaucoma in Eyes With Intermediate, Posterior, or Panuveitis Followed up to 10 Years After Randomization to Fluocinolone Acetonide Implant or Systemic Therapy
| Autor: | Multicenter Uveitis Steroid Treatment (Must) Trial, Michael M. Altaweel, Douglas A. Jabs, David S. Friedman, Elizabeth A. Sugar, Mark L. Van Natta, Lyndell L Lim, Susan G. Elner, Janet T. Holbrook, Husam Ansari, James P. Dunn, John H. Kempen |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraocular pressure genetic structures Visual Acuity Glaucoma Article 03 medical and health sciences 0302 clinical medicine Fluocinolone acetonide Risk Factors Ophthalmology Panuveitis medicine Humans Prospective Studies Prospective cohort study Glucocorticoids Intraocular Pressure 030304 developmental biology Drug Implants 0303 health sciences business.industry Incidence Hazard ratio Uveitis Posterior Middle Aged medicine.disease eye diseases Vitreous Body Treatment Outcome Fluocinolone Acetonide 030221 ophthalmology & optometry Female sense organs Implant business Uveitis Intermediate Uveitis Follow-Up Studies medicine.drug |
| Zdroj: | Am J Ophthalmol |
| ISSN: | 0002-9394 |
| Popis: | PURPOSE: To evaluate long-term risk and outcomes of glaucoma in eyes with intermediate, posterior, and panuveitis managed with systemic or fluocinolone acetonide (0.59 mg, “implant”) therapy. DESIGN: Prospective Follow-up of the Multicenter Uveitis Steroid Treatment (MUST) Clinical Trial Cohort METHODS: Patients with intermediate, posterior or panuveitis randomized to implant or systemic therapy (corticosteroid plus immunosuppression in >90%) were followed prospectively for glaucoma incidence and outcome. RESULTS: Among 405 uveitic at-risk eyes of 232 patients (median follow-up=6.9 years), 40% (79/196) of eyes assigned and treated with implant and 8% (17/209) of eyes assigned and treated with systemic therapy (censoring eyes receiving an implant upon implantation) developed glaucoma (Hazard Ratio (HR)=5.9 (95% CI: 3.2, 10.8); p |
| Databáze: | OpenAIRE |
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