Serum Pentraxin 3 is associated with signs of arterial alteration in women with preeclampsia
Autor: | Anna-Karin Wikström, Marita Larsson, Anders Larsson, Gerhard Wikström, Tansim Akhter, Tord Naessen |
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Rok vydání: | 2017 |
Předmět: |
Adult
medicine.medical_specialty Carotid Artery Common Inflammation Disease 030204 cardiovascular system & hematology Carotid Intima-Media Thickness Gastroenterology Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Internal medicine medicine.artery medicine Humans cardiovascular diseases Common carotid artery 030219 obstetrics & reproductive medicine business.industry Gestational age PTX3 medicine.disease Serum Amyloid P-Component C-Reactive Protein medicine.anatomical_structure Endocrinology cardiovascular system Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers Artery |
Zdroj: | International Journal of Cardiology. 241:417-422 |
ISSN: | 0167-5273 |
Popis: | Preeclampsia (PE) in pregnancy is a state of exaggerated inflammation and is associated with an increased risk of cardiovascular disease (CVD) later in life. Levels of pentraxin 3 (PTX3), a novel inflammation marker, are increased during PE and in individuals with CVD. The primary aim of this study was to assess whether serum PTX3 in women with PE is associated with adverse arterial effects; a thicker intima and higher intima/media (I/M) ratio in the common carotid artery (CCA).Serum PTX3 levels were measured using commercially available enzyme-linked immunosorbent assay kits, and individual CCA intima and media thicknesses were estimated by 22MHz non-invasive ultrasound in 55 women at PE diagnosis and 64 women with normal pregnancies at a similar gestational age, and about one year postpartum. A thick intima, thin media and high I/M ratio indicate a less healthy artery wall.During pregnancy serum PTX3 correlated positively with intima thickness and I/M ratio but negatively with media thickness (all p0.0001), indicating adverse arterial effects. About one year postpartum, PTX3 levels had decreased in both groups and there remained no significant group difference or significant correlation with CCA wall layers.Higher levels of serum PTX3 in women with PE were significantly associated with signs of adverse arterial effects during pregnancy, but not one year postpartum, supporting the rapid dynamics of PTX3. |
Databáze: | OpenAIRE |
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