Analgesic sesquiterpene dilactone from Mikania cordata
| Autor: | Jamil A. Shilpi, M Alimuzzaman, Muniruddin Ahmed, Mahmudur Rahman |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Analgesic Pain Pharmacognosy Asteraceae Sesquiterpene law.invention Mikania cordata chemistry.chemical_compound Acetic acid Lactones Mice Sesquiterpenes Germacrane law Drug Discovery Medicine Animals Acetic Acid Pain Measurement Pharmacology chemistry.chemical_classification Analgesics biology Traditional medicine Dose-Response Relationship Drug business.industry Plant Extracts General Medicine biology.organism_classification chemistry Phytotherapy business Sesquiterpenes Lactone |
| Zdroj: | Fitoterapia. 72(8) |
| ISSN: | 0367-326X |
| Popis: | The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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