T lymphocytes and preeclampsia: The potential role of T‐cell subsets and related MicroRNAs in the pathogenesis of preeclampsia
| Autor: | Mohammad Ali Zolfaghari, Farhad Motavalli Khiavi, Reza ArefNezhad, Forough Parhizkar, Mehdi Yousefi, Mohammad Saeid Hejazi, Ata Mahmoodpoor |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Spiral artery
Placenta T cell Immunology Blood Pressure T-Lymphocytes Regulatory Preeclampsia Proinflammatory cytokine Pathogenesis Endometrium Chemokine receptor Immune system Pre-Eclampsia Pregnancy Animals Humans Immunology and Allergy Medicine business.industry Obstetrics and Gynecology Trophoblast T-Lymphocytes Helper-Inducer medicine.disease MicroRNAs medicine.anatomical_structure Cellular Microenvironment Gene Expression Regulation Reproductive Medicine Cytokines Female business Signal Transduction |
| Zdroj: | American Journal of Reproductive Immunology. 86 |
| ISSN: | 1600-0897 1046-7408 |
| DOI: | 10.1111/aji.13475 |
| Popis: | Innate and adaptive immune systems have a crucial role in initiating and progressing some pregnancy disorders such as preeclampsia (PE), which is one of the pregnancy-specific disorders that could result in neonatal and maternal morbidity and mortality. The dysregulation of the spiral artery and inadequate trophoblast invasion lead to PE symptoms through producing various inflammatory cytokines and anti-angiogenic factors from the placenta. T lymphocytes play a special role in the epithelium and stroma of the human endometrium. CD4+ T helper (Th) cells, Th1/Th2, and Th17/T regulatory (Treg) balance mainly contribute to the establishment of a pregnancy-favorable environment. This review examined the dysregulation of some cytokines produced from T cells, the dysregulation of the transcription factors of Th cells, the expression of chemokine receptors on T cells, as well as the effects of some factors including vitamin D on the activity of T cells, and finally, the dysregulation of various miRNAs related to T cells, which could cause PE. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text